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最准的六合彩论坛 Division of Surgery and Interventional Science

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Responsive Oncotherapeutics

Professor Nomikou's research focuses on developing translational drug delivery approaches based on formulations / carriers that are responsive to forms of energy (electromagnetic fields, ultrasound) as well as the cancerous microenvironment.

Our work

Professor Nomikou's research demonstrates the potential of site-specific and minimally-invasive treatments based on low-intensity ultrasound (sonodynamic therapy) and light (photodynamic / photothermal therapy). The Responsive Oncotherapeutics group aims to optimise therapeutic modalities using nanotechnology and maximise their potential in clinic.

The group research has mainly focused on the design and development of polyglutamate-based nanoparticle formulations for improving the delivery of sensitizers to tumours in order to maximize the effect of site-specific tumour ablation using ultrasound and/or light. The effect of these treatment modalities in the induction of antitumour immune responses that can further augment tumour ablation are also being investigated in the context of their studies.

More recently, Professor Nomikou's team developed strategies to improve tumour responses to sonodynamic therapy, by identifying cancer cell defences of varying nature, depending on the tumour microenvironment conditions, and by subsequently applying combination treatment with agents that inhibit the relevant defence mechanisms. Thus far, the work has been focused on the treatment of prostate, pancreatic and colorectal cancers.

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Group members

Prof. Nikolitsa Nomikou

Head:

Dr Fabiola Scisione

, Research Associate

Ilona Kubajewska

Dr Ilona Kubajewska, Research Associate

Research students

Maryam Hadi

Maryam Mohammed Hadi (2017-)

PhD Project:聽Optimising sonodynamic therapy to treat prostate and pancreatic cancer.

Shiv Patel

(2017-)

PhD Project:聽Developing聽tumour-responsive nanoparticles to treat pancreatic cancer.

Hamzah Masood

(2019-)

PhD Project:聽Investigating secondary effects of sonodynamic therapy to treat prostate cancer.

Ed Duffy

Ed Duffy (2019-)

Project:聽Investigating the apoptotic effect of RGD peptide to treat metastatic cancer.

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听(2021-)

Project:聽Optimising sonodynamic therapy for the treatment of advanced colorectal cancer.

Yidong Wang

Yidong Wang (2022-)

Project:聽Designing novel multifunctional nanoparticle formulations for augmenting the effect sonodynamic therapy in cancer.

Funding / Partnerships

Research is funded by the UK Research Councils (EPSRC, MRC), the Royal Society, as well as UK-based cancer charities (e.g., Bowel & Cancer Research). Dr Nomikou鈥檚 work has also been supported by private donations.

Selected publications

  1. Farrell, S., Nicholas, D., Nesbitt, H., Logan, K., Nomikou, N., et al. (2021). . British Journal of Surgery, 108 (9),聽znab430.235.
  2. Hadi, M.M., Farrell, S., Nesbitt, H., Thomas, K., Kubajewska, I., Ng, A., Masood, H., Patel, S., Sciscione, F., 鈥�, Nomikou, N. (2022) . J Cancer Res Clin Oncol.
  3. Nicholas, D., Nesbitt, H., Farrell, S., Logan, K., Nomikou, N., et al. (2021). . European Journal of Pharmaceutics and Biopharmaceutics, 163, 49-59.
  4. Hadi, M.M., Masood, H., Sciscione, F., Patel, S., Nomikou, N., et al. (2021). . J Control Release, Jan 10;329:76-86.
  1. Nomikou, N. (2020). . US Patent Application,聽16/385591.
  2. Logan, K., Foglietta, F., Nesbitt, H., Nomikou, N., et al. (2019). . European Journal of Pharmaceutics and Biopharmaceutics, 139, 224-231.
  3. Nomikou, N.,聽Feichtinger, G.A.,聽Saha, S.,聽Nuernberger, S.,聽et al. (2018)聽.听J Tissue Eng Regen Med,听12:听别250鈥撀爀260.
  4. Tarassoli, S.P., MacRobert, A., ...,聽Nomikou, N., et al. 2017. . Nanotechnology, 28 (5).

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