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最准的六合彩论坛 Division of Surgery and Interventional Science

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Nanomedicine and Surgical Theranostics

The Centre for Nanomedicine and Surgical Theranostics (CNS) carries out translational multidisciplinary research on nanomedicine and targeted therapy and diagnostics of solid cancers and diseased lesions.

We recently optimised the manufacture of 3D tumouroid constructs using cells from patients with renal cancers, and then used these 3D constructs to test the efficacy of clinical drugs. Our vision is to develop this as a platform for personalised medicine, to predict the response to drugs of each patient with cancer.

We recently optimised the manufacture of 3D tumouroid constructs using cells from patients with renal cancers, and then used these 3D constructs to test the efficacy of clinical drugs. Our vision is to develop this as a platform for personalised medicine, to predict the response to drugs of each patient with cancer.

Our work

Our current research aims include:

  • New nanoparticles for surgical oncology to enable improved intraoperative imaging and targeted therapy.聽
  • Investigation of ablative techniques for surgery (e.g., ultrasound, near-IR irradiation, cryotherapy) and their combination with chemotherapy as adjuvants to surgery.
  • Developing tumouroid 3D in vitro cultures of cancer, which mimic the composition and architecture of solid tumours as platforms for testing therapeutics and stratified medicine.
  • Clinical trials in surgical oncology and renal cancer ablation and diagnostics.
  • Treatment of infections using nanoparticles with antimicrobial properties.

Our facilities

  • 3D model fabrication and culture of primary cells for cancer
  • Nanoparticle manufacture
  • Reactive oxygen species detection using time-resolved spectroscopy
  • High power laser irradiation
  • Ultrasound delivery
  • Thermal imaging
  • NIR imaging

The Centre for Nanomedicine and Surgical Theranostics (CNS)

Principal Investigators from laboratory and surgical disciplines work alongside postdoctoral, graduate researchers and students. To foster our interdisciplinary approach, we have strong links with other 最准的六合彩论坛 departments, including Chemistry, the School of Pharmacy and Engineering.

Prof. Sandy Macrobert

贬别补诲:听

Prof. Nikolitsa Nomikou

Deputy 贬别补诲:听

Prof. Marilena Loizidou

Maxine Tran

Dr Elnaz Yaghini

Prof. Axel Bex

Dr Katerina Stamati

Mohammed Eddama

Jajini Varghese

Muneer Ahmed

Prof. Faiz Mumtaz

Mr Reza Mirnezami

Mr Massimo Varcada

Silhouette in a circle. In light grey.

Silhouette in a circle. In light grey.

Dr Hazel Welch

Silhouette in a circle. In light grey.

Honorary staff

Pilar Acedo

Rifat Hamoudi

Cell under a microscope lens

Funding / Partnerships

Current research funding is drawn from the EPSRC, MRC, Innovate UK, British Council, NIHR (National Institute for Health Research), the Royal Society UK,聽and charitable sources.

We also work closely with industrial partners. An example of this is nanoparticle testing in experimental cancer models.

Select publications

  1. Neves JB, Warren H, Santiapillai J, Rode N, Cullen D, Pavlou M, Walkden M, Patki P, Barod R, Mumtaz F ...聽Gurusamy K, Emberton M, Bex A, Tran MGB (2023). . Eur Urol. 2023 S0302-2838(23)03012-9.

  2. Banerjee SM, Acedo P, El Sheikh S, Harati R, Meecham A, Williams NR, Gerard G, Keshtgar MRS, MacRobert AJ, Hamoudi R (2023).听. Front Immunol. 2023 14:1188087.

  3. Hadi MM, Farrell S, Nesbitt H,聽... MacRobert AJ, McHale JP, Nomikou N. et al. (2022). . J Cancer Res Clin Oncol.
  4. Eddama, M.M.R., Gurung, R., Fragkos, K., Lorgelly, P., Cohen, R., Loizidou, M., & Clapp, L. (2022). . Cancer Medicine.
  5. Nyga A., Stamati K., Hamoudi R., Tran M.G.B., Emberton M., Loizidou M.,聽Cheema U., et al.聽. J. Cell Commun. Signal. 2022.
  6. Hadi M.M., Sciscione F., Emberton M., MacRobert A., McHale A.P., Nomikou N., et al.聽. J.Control Release. 2021 Jan 10;329:76-86.
  1. Stamati K., Neves J.B., Tran M.G., Emberton M, Cheema U, Loizidou M.J., et al.聽. Tissue Eng. 2020 11:2041731420920597
  2. Hwang G.B., Huang H., Wu G., Shin J., Kafizas A.,聽MacRobert A.J., et al. . Nature Com. 2020 11(1):1207.
  3. Banerjee S.M., El-Sheikh S., Malhotra A., Mosse C.A., MacRobert A.J., Hamoudi R., et al.聽. J Clin. Med. 2020 10;9(2):483.
  4. Gulamhusein A., Silva P., Cullen D., Tran M., Mumtaz F., Bex A., et al.聽. BJU Int. 2020.
  5. Owusu EGA, MacRobert AJ, Naasani I, Parkin IP, Allan E, Yaghini E. . ACS Appl. Mater. Interfaces. 2019 11(13):12367-12378.
  6. Azimi T, Loizidou M, Dwek MV. . Sci Rep. 2020 21;10(1):12020.
  7. Neves JB, Cullen D, Grant L, Gurusamy K, Emberton M, Bex A, Tran MGB., et al.聽. BMJ Open. 2019 11;9(6):e030965.

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