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最准的六合彩论坛 Division of Surgery and Interventional Science

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Materials Research

Our translational work combines biotechnology and biomaterials science, with strong input from orthopaedic surgeons and clinicians. The team comprises bioengineers, material scientists, biochemists, and surgeons. Our research is directed toward biomedical devices innovation for enhancing the treatment of musculoskeletal disorders.

Our work

Our goal is to address clinically relevant challenges related to tissue engineering of the musculoskeletal system.

Key research

  • Scaffold innovation for musculoskeletal tissue engineering and regenerative medicine.
  • Customized medical devices for intervention of musculoskeletal disorders.
  • Biomedical device surface processing for regulate protein adsorption and cells attachment.
  • Biomaterials and additive manufacturing innovation early treatment of orthopaedic disorders.

Work in progress

  • Developing osteochondral scaffolds for early intervention in osteoarthritis.
  • Simulation and modelling of tissue-implant interactions.
  • Development of new biodegradable polymeric drug delivery systems.
  • Additive manufacturing and biomaterials innovation for treatment of orthopaedic disorders.
  • Surface modification of orthopaedic implants for regulating protein adsorption and cells growth.
  • Customised implants for reconstruction of large bone defects

Core research projects

  • Osteochondral scaffold innovation for early intervention of osteoarthritis
  • Personalised porous implants for reducing stress shielding and aseptic loosening.?
  • Orthopaedic applications
  • Titanium/PEEK reinforced collagen hybrid scaffold for large bone defect reconstruction.
  • Biomimetic bone-tendon tissue connector for repair of irreparable rotator cuff
  • Implant surface processing for regulate protein adsorption and tissue-implant interactions.

Nanosurface diagram, with nanoconcave and nanoconvex

Professor Chaozong Liu

Professor Liu’s research is directed toward biomaterials innovation for orthopaedic applications with particular emphasis on the early treatment of musculoskeletal disorders and improving musculoskeletal tissue repair and regeneration. His research in this area is supported by Versus Arthritis UK, Innovate UK, Horizon2020, NIHR, EPSRC and MRC.?Research from the Orthopaedic Group has led to several patented inventions, including the osteochondral scaffold technology for?regeneration of bone and cartilage for early intervention of osteoarthritis.

This scaffold was demonstrated by Professor Noel Fitzpatrick of the Channel 4 TV series Supervet. It was implanted in a pet dog shoulder to treat a large osteochondral defect. In 2017, the Versus Arthritis UK treatment sub-committee deemed the osteochondral scaffold "an exciting technology with the potential to provide a novel intervention for a large number of patients and potentially provide good value for money for the health services". It was awarded a grant for first-in-man clinical trials which began 01 October 2019 in the Royal National Orthopaedic Hospital.

Chaozong Liu

Chaozong Liu's Research Group

Tina Varma

(2020-)

Haoyu Wang

(2019-)

Ying Gu

Ying Gu (2018-)

Weizhe Xiao

Weizhe Xiao (2019-)

Liqi Ng

(2019-)

Tao Nan

(2022-)

Mingjing Zhang

(2022-)

Mo Zhou

(2020-)

Jianping Zhang

Jianping Zhang?(2023-)

Taotao Zhao

Taotao Zhao (2023-2024)

Alumni

  • Ziyu Liu (PhD, 2021) |?
  • Jiajun Luo (PhD, 2020) |?
  • Elena Giusto (PhD, 2019) |? (ITAP)
  • Shen-Mao?Chen |?Bisphosphonate-loaded nanoparticles for drug delivery in osteoporosis
  • Sara Ajami (Postdoctoral, 2017) |?Explant/ex-vivo models.?Shoulder implant failure in osteoarthritic patients and investigated the use of polyetheretherketone in uncemented shoulder resurfacing arthroplasty.
  • Dr Jeremy Mortimer (Postdoctoral, 2021-2022)
  • Dr Maryam Tamaddon (Postdoctoral, 2014-2022)
  • Seyed Ataollah Naghavi (PhD, 2023) 3D fabrication of short-stem porous hip implant for orthopaedic application?

Visiting scientists

  • Dr Zaida Cristina Ortega Medina (University of Las Palmas)
  • Dr Ruben Paz (University of Las Palmas)
  • Noella Diaz (University of Las Palmas)
  • Maria Elena Aleman (University of Las Palmas)
  • Dr Lingling Zhao (Ningbo University)
  • Lei Gao (Zhejian University)
  • Dr Narjes Rashidi (Tehran University of Medical Sciences)
  • Dr Dongmei Yu (Orthopaedics, Tangdu Hospital)
  • Dr Man Hao (Guangzhou University of Chinese Medicine)

Materials Research Group with Prof. Chaozong Liu on premises in Stanmore

Funding / Partnerships

  1. Engineering plant-based extracellular vesicles for anti-inflammatory and regenerative treatment of early osteoarthritis. 最准的六合彩论坛 Regenerative Medicine Tin Pilot Data Fund 2022.
  2. Novel hydrogel for cartilage regeneration. Shenzhen Science & Technology Community International Collaboration Grant. 2021.?
  3. Novel hybrid bone matrix for repair of irreparable rotator cuff tears. NIHR 最准的六合彩论坛H BRC Therapeutic Acceleration Support (TAS) Fund. 2021
  4. Development of a smart scaffold for monitoring the cell invasion. Royal Society. 2020
  5. Biotechnology of Jellyfish collagen scaffold. Jellagen Ltd. 2020.
  6. Titanium-Collagen Hybrid Scaffold Innovation for Large Bone Defect Reconstruction Following Osteosarcoma. EPSRC Doctoral Training Partnership - CASE Conversion Award. EPSRC. 2019
  7. Super elastic NiTiNb porous implant innovation for enhancing in vivo performance of joint reconstruction, Royal Society 2019. PI
  1. 3D Printing Technology of Integrated Material & Structure for Medical Application (材料结构一体化3D打印技术与医学应用), MoST China (National Key R&D Program of China). 2019?
  2. First in man clinical trials of novel osteochondral scaffold technology, Versus Arthritis Research UK. 2019
  3. Establish technical files for novel osteochondral scaffold, HEIF UK2018.
  4. Osteochondral Scaffold Innovation for Early Intervention of Osteoarthritis, Innovate UK-MoST ?2017
  5. Biomaterials and Additive Manufacturing: Osteochondral Scaffold innovation applied to osteoarthritis, EU – H2020-MSCA-RISE-2016 2017.
  6. Temperature and pH dual-responsive injectable rtPA-integrated nano-hydrogels for thrombolysis, Shenzhen International Collaboration Grant 2017.

Select publications

  1. Bakhtiary, N., Ghalandari, B.,?Ghorbani, F.,?Varma, S.N., Liu,?C. (2023) Advances in Peptide-Based Hydrogel for Tissue Engineering. Polymers. (In press)
  2. Jindi Lai, Anfu Chen, Jing Li, Yameng Pei, Seyed Ataollah Naghavi, Caihong Lei, Chaozong Liu, Lijia Huang. (2023).?. Journal of Materials Research and Technology.
  3. Seyed Ataollah Naghavi, Maryam Tamaddon, Pilar Garcia-Souto, Mehran Moazen, Stephen Taylor, Jia Hua and Chaozong Liu. (2023). . Frontiers in Bioengineering and Biotechnology-Biomechanics.
  4. Zhang Qiliang, Zhou Jian, Zhi Peixuan, Liu Leixin, Liu Chaozong, Fang Ao, Zhang Qidong. (2023). , 2023. 17: p. 100205.
  5. Deng, Shuhua, Anfu Chen, Weijia Chen, Jindi Lai, Yameng Pei, Jiahua Wen, Can Yang, Jiajun Luo, Jingjing Zhang, Caihong Lei, Swastina Nath Varma, and Chaozong Liu. 2023. .?Polymers. 2023. 15(1): 120.
  6. Jingfu Jin,Yiying Chen, Tingkun Chen, Yingchun Qi, Qian Cong, Chaozong Liu. (2023). . International Journal of Thermal Sciences. 2023. 185: 108090.
  7. Elena Giusto, Gordon Blunn, Roberta Ferro de Godoy, Chaozong Liu, Catherine Pendegrass. (2022).?. Biomaterials Translational. 2022. 3(4): 243-249.
  8. Hamidreza Tolabi, Negar Bakhtiary, Shaghayegh Sayadi, Maryam Tamaddon, Farnaz Ghorbani, Aldo R. Boccaccini, Chaozong Liu. (2022).?. Frontiers in Bioengineering and Biotechnology. 2022. 10:1008360.
  9. Tingkun Chen, Lin Wang, Jin Xu, Tianyu Gao, Xiuzhang Qin, Xiaobin Yang, Qian Cong, Jingfu Jin, Chaozong Liu. (2022).?. Machine. 2022. 10:1020.?
  10. Seyed Ataollah Naghavi, Churun Lin, Changning Sun, Maryam Tamaddon, Mariam Basiouny, Pilar Garcia-Souto, Stephen Taylor, Jia Hua, Dichen Li, Ling Wang, Chaozong Liu. (2022). . Polymers. 2022. 14, 4600.

  1. Li DP, Liu CZ, Jeremy M, Li X, Wang JC, Nath Varma S, Gai TT, Tian WQ, Zou Q, Wei YM, Wang HY, Long CJ, Zhou Y. (2022). . World Journal Clinical Cases. 2022. 10(28): 10227-10235.

  2. Seyed Ataollah Naghavi, Maryam Tamaddon, Arsalan Marghoub, Katherine Wang, Behzad Bahrami Babamiri, Kavan Hazeli *, Wei Xu, Xin Lu, Changning Sun, Liqing Wang, Mehran Moazen, Ling Wang, Dichen Li, Chaozong Liu. (2022).?. Bioengineering. 2022. 9(10):504.

  3. Changning Sun, Huiyu Zhao, Lei Wang, Jinghua Zhang, Jibao Zheng, Zijian Yang, Lijun Huang, Ling Wang, Chaozong Liu, Dichen Li, Qingchu Li. (2022). . Biomaterials Advances. 2022. 141:213119.

  4. Narjes Rashidi, Maryam Tamaddon, Chaozong Liu, Jan Czernuszka. (2022). . Polymer Testing. 2022. 116: 107796.

  5. Huanxin Wang, Xiangsheng Gao, Boxu Wang, Min Wang, Yunan Liu, Tao Zan, Peng Gao, Chaozong Liu. (2022).?. Medicine in Novel Technology and Devices. 2022. 16: 100174.

  6. Peixuan Zhi, Leixin Liu, Jinke Chang, Chaozong Liu, Qiliang Zhang, Jian Zhou, Ziyu Liu, Yubo Fan. (2022). . Metal. 2022. 12(9), 1500.

  7. Changning Sun, Jianfeng Kang, Ling Wang, Zhongmin Jin, Chaozong Liu, Dichen Li. (2022). .?Computer Methods in Biomechanics and Biomedical Engineering. 2022.

  8. Changning Sun, Enchun Dong, Jiayu Chen, Jibao Zheng, Jianfeng Kang, Zhongmin Jin, Chaozong Liu, Ling Wang, Dichen Li. (2022). . Journal of Functional Biomaterials. 2022, 13(3): 127.

  9. Luo Jiajun,?Zhao Shudong,?Gao Xiangsheng, Nath Varma Swastina,?Xu, Wei,?Tamaddon, Maryam,?Thorogate, Richard,?Yu, Haoran,?Lu, Xin,?Salmeron-Sanchez, Manuel,?Liu, Chaozong. (2022). . ACS Applied Materials & Interfaces. 2022. 14: 34400-34414.

Related courses

How to reach us

Centre for Materials Research
Division of Surgery & Interventional Science?
Royal National Orthopaedic Hospital
Brockley Hill
Stanmore
HA7 4LP

Tel: 0208 954 9427

We are located in Building 52