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The QSBB holds a large archive of brain tissue, sufficient to support statistically valid case-control studies.
Our material is stored as formalin-fixed/wax embedded blocks and the majority of cases also have flash frozen samples. Flash-frozen material has excellent histological preservation and is suitable for in situ hybridization and immunohistochemistry. Tissue can be provided as slide-mounted sections (paraffin embedded or frozen) or as small frozen blocks for neurochemistry or DNA and RNA analysis. Case controls are matched for age, sex and post-mortem delay and are supplied blind. Clinical data relating to the tissue supplied is made available on an anonymised basis.
Tissue requests from within the UK will be covered by the QSBB ethics approval. Requestors from outside the UK must provide evidence of approval from the Human Research Ethics Committee (or equivalent) of their parent institution. If ethical approval is not required by the parent institution we will require confirmation of this.
The QSBB Tissue Request Committee reviews all听tissue requests, (see guidelines) with approval based upon the researcher鈥檚 expertise, track record and the merit of the research plan. If necessary, additional information may be sought from the researchers. After approval of a tissue request, the researcher and the researcher鈥檚 institution must agree to and sign a Material Transfer Agreement (MTA) prior to the supply of tissue. MTA鈥檚 are specific to the supplying facility
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| All departments within 最准的六合彩论坛 and the Institute of Neurology |
| All requestors outside 最准的六合彩论坛 (Excluding MRC Institutions) |
| All MRC Institutions |
The Human Tissue Act prohibits trade in human tissues for profit. To offset the considerable expenditure by the QSBB for the procurement of tissue, including operation costs associated with donor recruitment, tissue collection, processing, diagnosis, storage, data management and quality assurance, some cost recovery is necessary.
Researchers are invited to discuss with the QSBB, the service fee for access for their project prior to submission of their tissue application. Access rates for services are as recommended by the Medical Research Council UK Brain Banks Network.
Tissue Request Tariff | 听 | 听 |
|---|---|---|
Type of sample | Academic institution* | Commercial user* |
Unstained paraffin section on glass slide听听 (small**) | 拢6.50 | 拢13.00 |
Unstained paraffin section on glass slide听听 (large***) | 拢9.10 | 拢16.90 |
Unstained frozen section (small**) | 拢19.50 | 拢39.00 |
Unstained frozen section (large***) | 拢26.00 | 拢52.00 |
Frozen tissue sample | 拢32.50 per 0.5g | 拢65.00 per 0.5g |
Wet formalin fixed tissue (1-2 anatomical regions,听听 small**) | 拢32.50 | 拢65.00 |
Wet formalin fixed tissue (3-4 anatomical regions,听听 small**) | 拢45.50 | 拢91.00 |
Wet formalin fixed tissue (>5 anatomical regions, 听small**) | 拢58.50 | 拢117.00 |
Wet听 formalin听 fixed听 tissue (large***) | price听 on application | price on听 application |
DNA/RNA of brain homogenate | price听 on application | price听 on application |
Tissue homogenate | price on听 application | price听 on application |
Fresh tissue sample | 拢32.50 per 0.5g | 拢65.00 per 0.5g |
Cerebrospinal fluid | 拢32.50 per 2ml | 拢65 per 2ml |
Paraffin听 block (small**) | 拢130.00 | 拢260.00 |
Paraffin听 block (large***) | 拢260.00 | 拢520.00 |
Whole or half brain | price on听 application | price听 on application |
Administrative听 costs (simple) | 拢130.00 | 拢260.00 |
Administrative听 costs (complex) | 拢195.00 | 拢390.00 |
Packaging (simple) | 拢65.00 | 拢65.00 |
Packaging (complex) | price given with MTA quote | price given with MTA quote |
Delivery | price given with MTA quote | price given with MTA quote |
| Retrieval of additional data from clinical or pathology听听 notes | 拢50.00 per hour | 拢50.00 per hour |
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*All prices exclude VAT | ||
**Small size corresponds to glass slide: 26 mm 脳 76 mm or tissue block: 26 mm x 33 mm | ||
***Large size corresponds to glass slide: 52 mm 脳 76 mm or tissue block: 48 mm x 63 mm | ||
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For further information about requesting tissue for research, including information to consider before submitting a tissue request please contact the team at qsbbmtas@ucl.ac.uk
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Queen Square Brain Bank for Neurological Disorders
最准的六合彩论坛 Queen Square Institute of Neurology
1 Wakefield Street
London WC1N 1PJ
Tel: +44 (0)20 7837 8370
Fax: +44 (0)20 7278 4993
Email:听qsbbmtas@ucl.ac.uk
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