Call now closed.
Strategic aims of the Precision AMR
- To break down existing barriers in AMR research
- Developing new diagnostics
- Improving quality and speed of results to wards
- Changing clinical management to reduce AMR
- Changing behaviours e.g. in prescribing medication for AMR infections
- Data science to support AMR research
- Understanding factors that lead to AMR e.g. audit and service evaluation
Precision AMR has funding available for 20 seed research projects, each with up to £16,000 to spend.
Eligibility
Lead applicant must hold a substantive contract with either ×î×¼µÄÁùºÏ²ÊÂÛ̳, ×î×¼µÄÁùºÏ²ÊÂÛ̳H and GOSH. Co-applicants may be other researchers, students, or external collaborators e.g. with other academic institutes/ industry/ research charities and research councils.
Each project proposal is strongly encouraged to use one (or more) of the facilities, where possible.
Can support
Each award will be primarily for consumables and additional facility costs (outside of the support Precision AMR already provides each facility), and can include salary costs. Any other costs will need to be discussed with the project manager in advance of submission for consideration.
Projects in microbiology, bacteriology, fungal and behavioural work as well as data science (data linkage, artificial intelligence and machine learning) work will be prioritised.
Cannot support
These awards will not be able to support animal work, proposals will animal work will need to clearly indicate how this is/ will be funded. Virology project proposals will not be considered as it is outside the scope of the funding to Precision AMR.
Details of the call, eligibility and funding criteria can be found on the below guidance form. Ìý
Projects in HIV and tuberculosis inÌýnovel interventions to prevent and treat healthcare-associated infections and infectious disease cannot beÌýsupported:Ìýapproaches to prevent and manage infections other than by antimicrobials, for example, through manipulating the microbiome; immunotherapies; phage therapy; vaccines also cannot be supported.
Application details
If you have any questions or queries, please contact us on: precision.amr@ucl.ac.uk
Call opens: Monday 3 AugustÌý
Deadline for application: Midnight, Sunday 11 OctoberÌý
Applicants notified by: Early November
Funding available from 1 December 2020 - 31 August 2021 (9 months).
Documents
Award holder
Successful project which were awarded funding are listed below
Lead Applicant | Project titleÌý |
---|---|
John Readman | Development of antisense/antigene agents based on synthetic oligonucleotides to inhibit carbapenemases and restore antibiotic sensitivity in resistant Klebsiella pneumoniae |
Özge Yetiş | Genomic characterisation of P. aeruginosa strains found in hospital shower water and inpatient bacteraemia isolates |
Jeremy Brown | Novel Polymyxin / Fusidic Acid Combination Therapies for the Treatment of Multi-drug Resistant Acinetobacter baumannii and Enterobacterales Infections |
Peter Dutey-Magni | Reducing exposure to unnecessary antibiotics in the emergency department through early and reliable prediction of bacteriuria using a comprehensively validated machine learning model |
Stephen Morris-Jones | The Hollow-Fibre Model of Mycobacterium abscessus Disease to test new antibiotics and combination therapy |
Joseph Standing | Cefepime-sulbactam as a promising combination for empirical treatment in high ESBL settings: a dose ranging hollow fibre infection model studyÌý |
Akuzike Kalizang’oma | A genomic approach to predict beta-lactam susceptibility among S. mitis using strains isolated from infective endocarditis patients over 18 years in the United Kingdom |
Vicky Enne | lementation of a rapid clinical metagenomics pipeline for the diagnosis of lower respiratory tract infections in critically ill patients at ×î×¼µÄÁùºÏ²ÊÂÛ̳H: a pilot studyÌý |
Francis Yongblah | Non-tuberculous Mycobacteria (NTM) in domestic and healthcare water supplies – a potential route of transmission to Cystic Fibrosis (CF) and other at-risk patient groups? |
Nidhi Kapil | Gold Nanoparticles Decorated on Stimuli-Responsive Polymer Brushes as Stable Anti-microbial Surfaces |
Nishkantha Arulkumaran | Novel DNA nanomaterials to capture bacteria |
Jennifer Rohn | Characterisation of the gut and urinary microbiome for predicting treatment-resistant urinary tract infection and its downstream complications in renal transplant recipients |
Victoria Heath | Transforming the diagnostic pathway for high risk clinical pathogens |
Dimitrios Evangelopoulos | Investigation of drug synergy and rational design of drug combinations to overcome multidrug-resistant Escherichia coli infections |
Sarah LoganÌý | An observational study of culture negative urine in patients with lower urinary tract symptoms using metagenomic next generation sequencing |
Bruce Macrae | Development of a WGS laboratory diagnostic pathway for the identification of M. genitalium and subsequent detection of relevant resistance targets |
Jane Currie | Understanding asymptomatic bacteriuria in early pregnancy – an observational cohort study of maternal and neonatal outcomes |
Vanya Gant | Developing a diagnostic WGS pathway for the characterisation of Aspergillus sp isolated from patients at risk of Invasive fungal infection: with focus on cyp51A gene profiling for the detection of azole resistance |
Mona Bajaj-Elliott | How do we mitigate the rise of ‘superbugs’ in a paediatric transplantation setting? |
Joseph Standing | Establishing the hollow fibre model of invasive candidiasis to investigate the impact of combination antifungal therapies on antifungal resistance |
Stephen Morris-Jones | Developing a diagnostic WGS pathway for the investigation of duodenal and gastric biopsies for the presence of H. pylori antibiotic resistance markers |
Nishkantha Arulkumaran | Antibiotic – induced immunosuppression |
Frank Kloprogge | Leveraging the hollow fibre infection model to reduce and replace animal experiments in antimicrobial drug development |
Vanya Gant | Developing a diagnostic WGS pathway for the characterisation of multi-drug resistant bacteria in outbreak situations |
Shanom Ali | Improving detection of Pseudomonas aeruginosa in hospital shower waters to characterise biofilm-communities using Whole Genome Sequencing to facilitate mapping of horizontal-transmission and persistence in the environment |
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