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Early Phase Cancer Trials Programme at ×î×¼µÄÁùºÏ²ÊÂÛ̳ and ×î×¼µÄÁùºÏ²ÊÂÛ̳H

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Haematology - Lymphoma & CLL Trials

A LIST OF OUR EARLY PHASE Haematology (Lymphoma & CLL)ÌýTRIALS WHICH ARE OPEN TO RECRUITMENT AT UNIVERSITY COLLEGE LONDON HOSPITALS

To find more information on ×î×¼µÄÁùºÏ²ÊÂÛ̳H Early Phase Cancer Clinical Trials, including eligibility criteria, click theÌýhyperlinkedÌýLocal Project Reference (LRP)ÌýID, which will take you to the ×î×¼µÄÁùºÏ²ÊÂÛ̳H Find a Study database.

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ALLCAR19

Immunotherapy for High Risk/Relapsed CD19+ Acute Lymphoblastic Leukaemia, B-cell Non-Hodgkin's Lymphoma (B-NHL) and Chronic Lymphocytic Leukaemia (CLL)/ Small Lymphocytic Lymphoma (SLL) Using CAR T-cells to Target CD19 (ALLCAR19)

Local Project Reference:
Principal Investigator:Dr Claire Roddie
Drug Class/ Treatrment:

CAR T-Cell Therapy

Expressing CD19 Chimeric Antigen Receptor (CD19CAR)

Patient Population:
  • Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (B-NHL)
  • Chronic Lymphocytic Leukaemia (CLL)
  • Small Lymphocytic Lymphoma (SLL)

AdultsÌý>/=16 years old

Trial Hosted By - ×î×¼µÄÁùºÏ²ÊÂÛ̳H Cancer Clinical Trials Unit (CCTU)

NAVAL-1

An Open-Label, Phase 2 Trial of Nanatinostat in Combination with Valganciclovir in Patients with Epstein-Barr Virus-Positive (EBV+) Relapsed/Refractory Lymphomas (NAVAL-1)

Local Project Reference:
Principal Investigator:Dr. Kirit Ardeshna
Drug Class/ Treatrment:NanatinostatÌý(Histone Deacetylase Inhibitor) + Valganciclovir (Antiviral Medication)
Patient Population:Epstein-Barr Virus-Positive (EBV+) Relapsed/Refractory Lymphomas
Trial Hosted By - ×î×¼µÄÁùºÏ²ÊÂÛ̳H Cancer Clinical Trials Unit (CCTU)

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On hold to recruitment

CO43805
A PHASE Ib, OPEN-LABEL, MULTICENTER STUDY EVALUATING THE SAFETY, PHARMACOKINETICS, AND EFFICACY OF MOSUNETUZUMAB OR GLOFITAMAB IN COMBINATION WITH CC-220 AND CC-99282 IN PATIENTS WITH B-CELL NON-HODGKIN LYMPHOMA

Local Project Reference:
Principal Investigator:Dr WIlliam Townsend
Drug Class/Treatment:

MosunetuzumabÌý(bispecific CD20-directed CD3 T-cell engager) orÌýGlofitamabÌý(CD20- and CD3- Bispecific Antibody)

In Combination withÌýCC-220Ìý(cereblon E3 ligase modulator) + CC-99282Ìý(E3 Ligase Modulator)

Patient Population:B-Cell Non-Hodgkin Lymphoma
Trial Hosted By - NIHR ×î×¼µÄÁùºÏ²ÊÂÛ̳H Clinical Research Facility (CRF)

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