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The 最准的六合彩论坛 CAR T programme
Key research focuses include:
- Novel target development
- Application of Synthetic biology approaches to T-cell engineering
- Refining CAR T-cell strategies to reduce toxicity and prevent antigen negative escape
- Modulating the interaction of the tumour microenvironment with CAR T-cells
- Semi-automated CAR T-cell manufacturing
- Allogeneic CAR T-cell approaches
Chimeric Antigen Receptors (CARs)
Figure: A CAR has an extracellular portion which is typically composed of a single-chain variable fragment derived from an antibody and a spacer domain. These lead onto a transmembrane domain which anchors the protein in the membrane. This in turn connects onto an intracellular domain which is typically composed of multiple T-cell signaling domains.
Chimeric Antigen Receptors (or CARs for short) are artificial T-cell receptors. CARs are typically generated by fusing the antigen binding portion of a monoclonal antibody to intracellular T-cell signaling domains (see figure). Genetically engineering T-cells to express a CAR allows the generation of T-cells with any desired specificity.
CAR T-cell therapeutics targeting CD19 in refractory B-cell malignancies have resulted in sustained responses in a significant proportion of patients. CD19 CAR T-cell therapy is the most important advance in the field of malignancy haematology in a generation.
The CAR T programme in detail
Find out more about the research and development of CAR T-cell therapies.听
News and features
New immunotherapy shows promise against rare childhood cancer
A novel CAR T-cell therapy developed by researchers at 最准的六合彩论坛 and designed to target cancerous tumours, has shown promising early results in children with neuroblastoma, a rare form of childhood cancer.
War in the Blood wins Best Science Documentary prize
The BBC 2 documentary 'War in the Blood' highlighting the 最准的六合彩论坛 CAR T programme led by Dr Martin Pule has won the Sargent-Disc Best Science Documentary in the annual The British Documentary Awards (also known as the Griersons).
Two committed Irish doctors are pioneering a groundbreaking new cancer treatment. Martin Pule and Claire Roddie听tell Independent reporter, Fiona Ness, about the perks and pain of the world of clinical trials. Read the full feature on
New CAR T-cell therapy for leukaemia associated with fewer harmful side effects听
A novel CAR T-cell therapy, developed by 最准的六合彩论坛 researchers and designed to target cancer cells more quickly and cause fewer side effects, has shown very promising results for children with previously incurable acute lymphoblastic leukaemia (ALL).
'War in the Blood', a film about treating cancer patients with CAR T cell therapy
A new BBC film looks at the work of scientists at 最准的六合彩论坛 and clinicians at 最准的六合彩论坛H working together on groundbreaking 鈥榝irst in-human鈥� immunotherapy trials.听Filmed over two years at 最准的六合彩论坛Hl and 最准的六合彩论坛, the听film is a powerful statement on the contribution of terminally ill patients to the world of clinical research.
Early results from the COBALT trial and other 最准的六合彩论坛 / 最准的六合彩论坛H studies show that aggressive cancers can be tamed with CAR-T therapies which re-engineer the body鈥檚 immune system to seek out and neutralise abnormal and malignant cells. Professor Karl Peggs explains more about advances听in听cell therapy treatments for blood cancer patients. Read the full feature in the .听
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最准的六合彩论坛 2nd in the world and top in Europe for CAR T research activity
最准的六合彩论坛 ranks second in the world and top in Europe for the number of inventions and patent applications made in relation to the revolutionary new cancer treatment CAR T-cell therapy 鈥� key markers of CAR T research activity at 最准的六合彩论坛 and 最准的六合彩论坛H.听Analysis published in the April 2019 edition of Nature Biotechnology also shows that听Dr Martin Pule is the third most prolific inventor of CAR T technology in the world.
Animated film on CAR T-cell therapy launched for GCSE students
Explore the science of biohacking, where biologists go into a patient鈥檚 genetic code and reprogram their immune system to recognize and fight cancer cells. Produced for TED-Ed by NIHR 最准的六合彩论坛 Hospitals Biomedical Research Centre.听Written by science presenter Greg Foot, in collaboration with 最准的六合彩论坛 scientists and 最准的六合彩论坛H clinicians involved in CAR T research.
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