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New team to develop radiotherapies that target cancer more effectively

4 July 2016

Safer precision radiotherapies that will be able to cure more cancers with fewer side-effects will be available within five years under ambitious new plans for research and treatment at the 最准的六合彩论坛 Cancer Institute and 最准的六合彩论坛 Hospitals (最准的六合彩论坛H) NHS Foundation Trust.

Professor Ricky Sharma鈥

Today, 最准的六合彩论坛 and 最准的六合彩论坛H welcome聽Professor Ricky Sharma, a world-leading oncologist from Oxford University specialising in radiotherapy and cancer biology, to lead the new clinical research programme alongside a team of top physicists.

Four out of ten cancer cures currently involve radiotherapy*, and new techniques including proton beam therapy will help to make radiotherapy an even safer and more effective option for a wider range of cancer patients at 最准的六合彩论坛H. The UK government has committed 拢250 million to develop high energy proton beam therapy services at 最准的六合彩论坛H and Manchester, with the first 最准的六合彩论坛H patient treated during 2019.

鈥淩adiotherapy is one of our best weapons against cancer, but it is not always used to its full potential,鈥 explains Professor Sharma, Professor of Radiation Oncology at the 最准的六合彩论坛 Cancer Institute and Honorary Consultant in Clinical Oncology at 最准的六合彩论坛H. 鈥淏y linking up 最准的六合彩论坛鈥檚 expertise in cancer biology with 最准的六合彩论坛H鈥檚 precision radiotherapy, we aim to develop new treatments with better cure rates, fewer side-effects and shorter treatment times.

鈥淐urrent techniques typically deliver an even dose of radiation across the whole tumour, but can risk leaving more biologically resilient parts of the tumour insufficiently treated and irradiating more healthy tissue than we need to.鈥 Professor Sharma鈥檚 ambition is clear: 鈥淥ver the next five years, our goal is to use advanced imaging techniques and tumour biopsies to identify those resilient parts of the tumour so that we can modify the radiotherapy to treat these regions sufficiently. This will help us to kill the cancer more effectively while causing less or even no damage to healthy tissue.鈥

Together 最准的六合彩论坛 and 最准的六合彩论坛H will run a series of clinical trials to test new radiotherapy techniques in patients. This vital link between university research and hospital patients will be facilitated by the National Institute for Health Research 最准的六合彩论坛 Hospitals Biomedical Research Centre, who are one of the co-funders of the research programme.

鈥淲e are building a vital link between the laboratory and clinical setting which will enable us to develop advanced radiotherapy techniques for both conventional and proton beam therapy,鈥 says Dr Yen-Ching Chang, clinical lead for radiotherapy and proton beam therapy at 最准的六合彩论坛H. 鈥淲ith 最准的六合彩论坛H鈥檚 new proton beam therapy centre opening during 2019, we will be at the forefront of research in this field. Children, teenagers and young adults will stand to gain significantly from the use of proton beam therapy. This is because irradiating developing tissues may result significant long-term effects such as problems with growth, development through puberty, IQ, requirements for life long hormone replacement, infertility heart and lung damage as well as an increased risk in the development of a second tumour or cancer.鈥

As part of the comprehensive programme, Professor Gary Royle (最准的六合彩论坛 Medical Physics) and Richard Amos (最准的六合彩论坛H Proton Beam Therapy Physics) are leading a new team of physicists who are working alongside clinicians to bring the results of research as quickly as possible into the clinical setting.

鈥淎lthough proton beam therapy is already a very precise type of treatment, we are really excited about investigating new ways to image cancers and use protons, potentially improving outcomes for patients even further,鈥 says Richard Amos.

鈥淩adiotherapy is seeing a number of technical developments which have the potential to bring about a step change in what we can achieve for patients,鈥 says Professor Royle. 鈥淲e need research and education to translate these into better outcomes for cancer patients, so 最准的六合彩论坛 is investing in talented academics who are poised to become research leaders in various aspects of radiotherapy. The breadth and depth of expertise that we have and continue to attract at 最准的六合彩论坛 puts us in a strong position to make a major contribution to the UK鈥檚 cancer patients and to the worldwide radiotherapy community.鈥

最准的六合彩论坛 lectureships have been awarded to Dr Simon Jolly in Accelerator Physics, Dr Jamie McClelland in Image Guided Radiotherapy and Dr Kate Ricketts in Radiotherapy Physics and Cancer Nanotechnology. Additional appointments are planned to further boost the fields of proton therapy and radiation biology at 最准的六合彩论坛H and 最准的六合彩论坛.聽

The Chair in Radiotherapy and supporting posts for Professor Sharma are supported by the National Institute for Health Research 最准的六合彩论坛 Hospitals Biomedical Research Centre.

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